דו״ח מאומת

Microplastics are ubiquitous environmental contaminants leading to inevitable human exposure. Even so, little is known about the effects of microplastics in human health. Thus, in this work we review the evidence for potential negative effects of microplastics in the human body, focusing on pathways of exposure and toxicity. Exposure may occur by ingestion, inhalation and dermal contact due to the presence of microplastics in products, foodstuff and air. In all biological systems, microplastic exposure may cause particle toxicity, with oxidative stress, inflammatory lesions and increased uptake or translocation. The inability of the immune system to remove synthetic particles may lead to chronic inflammation and increase risk of neoplasia. Furthermore, microplastics may release their constituents, adsorbed contaminants and pathogenic organisms. Nonetheless, knowledge on microplastic toxicity is still limited and largely influenced by exposure concentration, particle properties, adsorbed contaminants, tissues involved and individual susceptibility, requiring further research.…

PMID: 31733547

Microplastics (MPs) can be ingested by a variety of species and mainly accumulate in the gut. However, the consequences of MPs exposure in the gut are largely unknown. Here we evaluated the impacts of MPs exposure in zebrafish gut. Animals were experimentally exposed to polystyrene MPs (5-μm beads; 50 μg/L and 500 μg/L) for 21 days and monitored for alterations in tissue histology, enzymatic biomarkers, gut microbiome and metabolomic responses. Inflammation and oxidative stress were observed in the zebrafish gut after exposed to MPs. Furthermore, significant alterations in the gut microbiome and tissue metabolic profiles were observed, with most of these were associated with oxidative stress, inflammation and lipid metabolism. This study provides evidence that MPs exposure causes gut damage as well as alterations in gut metabolome and microbiome, yielding novel insights into the consequences of MPs exposure.…

PMID: 30690359

Microplastics and nanoplastics (MNPs) are ubiquitous environmental contaminants. Their prevalence, persistence, and increasing industrial production have led to questions about their long-term impact on human and animal health. This narrative review describes the effects of MNPs on oxidative stress, inflammation, and aging. Exposure to MNPs leads to increased production of reactive oxygen species (ROS) across multiple experimental models, including cell lines, organoids, and animal systems. ROS can cause damage to cellular macromolecules such as DNA, proteins, and lipids. Direct interaction between MNPs and immune cells or an indirect result of oxidative stress-mediated cellular damage may lead to increased production of pro-inflammatory cytokines throughout different MNP-exposure conditions. This inflammatory response is a common feature in the pathogenesis of neurodegenerative, cardiovascular, and other age-related diseases. MNPs also act as cell senescence inducers by promoting mitochondrial dysfunction, impairing autophagy, and activating DNA damage responses, exacerbating cellular aging altogether. Increased senescence of reproductive cells and transfer of MNPs/induced damages from parents to offspring in animals further corroborates the transgenerational health risks of the tiny particles. This review aims to provoke a deeper investigation into the notorious effects these pervasive particles may have on human well-being and longevity.…

PMID: 39513895

Humans are exposed to micro-and-nano plastics (MNPs) through various routes, but the adverse health effects of MNPs on different organ systems are not yet fully understood. This review aims to provide an overview of the potential impacts of MNPs on various organ systems and identify knowledge gaps in current research. The summarized results suggest that exposure to MNPs can lead to health effects through oxidative stress, inflammation, immune dysfunction, altered biochemical and energy metabolism, impaired cell proliferation, disrupted microbial metabolic pathways, abnormal organ development, and carcinogenicity. There is limited human data on the health effects of MNPs, despite evidence from animal and cellular studies. Most of the published research has focused on specific types of MNPs to assess their toxicity, while other types of plastic particles commonly found in the environment remain unstudied. Future studies should investigate MNPs exposure by considering realistic concentrations, dose-dependent effects, individual susceptibility, and confounding factors.…

PMID: 38061242

Microplastics have become a serious environmental pollutant that enter different ecosystems and eventually the human body through direct exposure to the environment. This infiltration is a major health risk, especially for the liver, which is a primary metabolic organ highly sensitive to the harmful effects of microplastics. There are many ways that these particles can cause liver damage, such as disrupting metabolism, inducing oxidative stress, causing mitochondrial dysfunction, causing inflammation, changing gene expression, and activating abnormal signaling pathways. Even in the absence of hepatic fibrosis or cirrhosis, the carcinogenic potential of microplastics may exert its effects through different pathways. In addition, microplastics can act as efficient vectors for the transport of heavy metals, organic pollutants, and pathogenic microorganisms, thereby synergistically amplifying the toxic effects of these agents and increasing health risks. The complex interactions between microplastics and various pathological processes underscore their critical role in the development of hepatocellular carcinoma. Future research endeavors should focus on elucidating the long-term health impacts of microplastic exposure to devise effective public health policies and preventive strategies.…

PMID: 41864538

Microplastics and nanoplastics (<5 mm and <1 μm, respectively) are emerging contaminants now ubiquitous across environmental matrices and increasingly recognized for their impacts on human health. These particles commonly adsorb or contain endocrine-disrupting chemicals-such as bisphenol-A and phthalate additives-that together trigger complex biological responses. This review examines the central role of oxidative stress in mediating the toxicity of microplastics and associated endocrine disruptors across multiple organ systems. We discuss mechanisms including cellular uptake, reactive oxygen species generation, mitochondrial dysfunction, impairment of antioxidant defenses, and activation of key signaling pathways. Organ-specific effects on reproductive health, cardiovascular function, hepatic metabolism, gut barrier integrity, and neurological systems are highlighted. Current evidence strongly supports oxidative stress as a pivotal mechanism linking microplastic exposure to systemic toxicity, underscoring important implications for public health policy and clinical intervention strategies.…

PMID: 41516273

Male infertility stands as a significant global concern, contributing to nearly 50% of infertility cases and affecting approximately 7% of the male population. Mounting evidence identifies environmental degradation is a major, modifiable driver. Numerous environmental contaminants, including air pollution, heavy metals, endocrine-disrupting chemicals (EDCs), microplastics, pharmaceutical contaminants, and climate change linked to deteriorating semen quality. These environmental toxins can decrease spermatogenesis and overall sperm function by triggering oxidative stress, hormonal imbalance, inflammation, and epigenetic alterations. This review highlights the increasing necessity of incorporating environmental exposure data (eco-profiles) into routine semen analysis. An integrated framework is outlined in which AI algorithms analyze multi-omics biomarkers, ranging from genomics to metabolomics, together with environmental metrics. These combined data are used to predict individual fertility risk and to guide personalized treatment strategies, particularly in the context of assisted reproductive technologies. Future studies are essential to find trustworthy biomarkers and elucidate the molecular processes that connect environmental contaminants to male infertility. As environmental toxicants intensify, the comprehensive toxicological studies are in need to enhance curative approaches and preventative strategies that ultimately aim at safeguarding male fertility.…

PMID: 41788722

This FIGO committee opinion paper addresses the growing body of evidence linking environmental exposures to common gynecologic and reproductive conditions across the life course. From adolescence through menopause, women are exposed to a wide range of environmental toxicants, including endocrine-disrupting chemicals, air pollutants, heavy metals, pesticides, and industrial compounds, which influence hormonal function, ovarian reserve, and disease risk. This article synthesizes high-quality systematic and authoritative reviews along with high-quality literature on exposures that can increase the risk of infertility, polycystic ovary syndrome, endometriosis, uterine fibroids, hormonally mediated cancers, and menopause. It highlights underlying mechanisms, such as endocrine disruption, oxidative stress, inflammation, and epigenetic modification. Importantly, the article emphasizes disparities in exposure and outcomes, particularly among historically marginalized populations with heightened vulnerability to environmental injustice. Practical guidance is offered to help clinicians incorporate environmental health into routine care, through patient counseling, exposure screening, and advocacy. The article calls for obstetrician/gynecologists to take leadership roles in recognizing environmental risk as a determinant of reproductive health and equity-both within the clinic and through systems-level policy change.…

PMID: 41001939

The therapeutic potential of functional nutrients has garnered considerable attention for enhancing resilience signaling and counteracting the damage to human health caused by microplastic pollutants. The intricate interactions between microplastics (MPs) and nanoplastics (NPs) and functional nutrients, including polyphenols, flavonoids, phenylpropanoids, phenolic acids, diterpenoids, and triterpenoids, have been shown to improve blood-brain barrier (BBB) homeostasis and brain function by inhibiting oxidative stress, ferroptosis, and inflammation linked to the pathogenesis of metabolic and brain disorders. Interestingly, nutrients exhibit biphasic dose-response effects by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and stress-resilience proteins at minimum doses, thereby preventing or blocking MP and NP-induced damage. Notably, chronic exposure to environmental pollutants causes aberrant regulation of <i>NFE2L2</i> gene and related antioxidant signaling, which can exacerbate selective susceptibility to brain insulin resistance under inflammatory conditions. This, in turn, impairs glucose metabolism and facilitates β-amyloid (Aβ) plaque synthesis leading to the onset and progression of Alzheimer's disease (AD), also known as "Type 3 diabetes". This pathological process triggered by oxidative stress, inflammation, and ferroptosis creates a vicious cycle that ultimately contributes to neuronal damage and loss. The review aims to investigate the therapeutic potential of functional nutrients targeting the Nrf2 pathway and stress resilience proteins to regulate epigenetic alterations, and to explore the underlying molecular mechanisms using innovative in vitro platforms for the development of promising preventive strategies and personalized nutritional interventions to attenuate oxidative stress, ferroptosis, and inflammation, with the goal of ultimately improving clinical outcomes.…

PMID: 41516048

Microplastics (MPs) is defined as plastic particles less than 5 mm. MPs have become a major environmental pollutant and it is originating from the breakdown of larger plastic waste. This article aims to explore MPs exposure to human health, particularly its potential effects during early developmental years. Studies reveal that MPs exposure begins via intra-uterine route, where MPs were detected in the placenta, amniotic fluid, umbilical cord, fetal membranes, and umbilical vein blood. As infants developed, the MPs exposure continued via breast milk, milk storage bags, formula, feeding bottles, and even from pacifiers. During early childhood, exposure routes can be from 3 different routes, including dermal contact (clothing, childcare products), ingestion (bottled milk, school dust, playground sand, sugar, salt), and inhalation (toy blocks, play mats, indoor air). The review also highlights the potential health risks to vital organs and systems from prenatal as well as postnatal MPs exposure in <i>in vivo</i> studies. These includes the optical, neurological, cardiovascular, pulmonary, hepatic, urinary, digestive, skeletal, lymphatic and reproductive systems. Given their small size and potential toxicity, MPs may disrupt these important developmental processes, leading to long-term health consequences. This article explores the route of MPs exposure with the potential severity and health impacts of those exposure, especially for fetuses, infants, and children. By doing so, it aims to identify any missing knowledge in this area. This research will serve as a foundation for designing future studies that identify health risks in generations exposed to MPs from a very young age.…

PMID: 41146921

The deposition of airborne microplastics (MPs) poses potential risks to human health and terrestrial ecosystems. Therefore, suitable mitigation efforts are needed, as is knowledge of their deposition patterns in inhabited and remote regions. Currently, there are no standardized protocols for monitoring airborne MPs, and implementing and managing automatic monitoring systems would be costly and feasible only in a few fixed locations. Over the past few decades, several species of cryptogams have proven to be reliable biomonitors of persistent atmospheric contaminants. Due to the lack of standardized methodologies, the results of preliminary biomonitoring surveys for MPs have been inconsistent and difficult to compare. However, they clearly indicate higher MP concentrations in epigeic mosses than in epiphytic lichens (collected at the same site or experimentally exposed in parallel in bags). This review discusses the morphophysiological features that favor the entrapment and retention of intercepted MPs in mosses, as well as the field and laboratory activities necessary to determine whether these organisms progressively accumulate airborne MPs as a function of the exposure time. Steps for future research needed to develop a cost-effective, reliable and easily applicable biomonitoring methodology are suggested. Evaluating the advantages of active moss biomonitoring over sampling atmospheric bulk deposition or exposing suitable commercial materials is recommended.…

PMID: 41718264

Microfiber pollution is one of the recent threats to sustainability. Due to the increased use of synthetic textiles, microplastic fiber release to the environment has increased exponentially. This review aims to analyze the existing literature to identify the potential preventive measures to control microfiber pollution. The review consolidates the findings under the textile properties and laundry product category. The review results show that the use of finer count yarns with filaments and compact structures reduces microfiber shedding. Similarly, mechanical finishes like shearing and raising increase the microfiber release as they damage the fabric structure. A significant increment is noted in microfiber reduction percentage after the chemical (coating) finishing process. In the case of commercial products, the available external laundry filters are reported as more efficient than the in-drum devices in the market. An analysis of the existing regulatory norms showed that very few countries had developed their laws, and no global regulation and standards were found to test microfiber pollution. In the case of laundry filters, though they filter microfiber effectively, they do not prevent it, so it can be a control measure and not a solution for the issue. Out of the review results, it is identified that controlling the textile parameter is the only effective strategy to prevent the microfiber shedding from the synthetic textile. A proper production method and parameter will yield a textile that sheds lesser or no microfiber. However, no detailed research works are found in correlating these parameters together and indicate the potential scope for future research.…

PMID: 34100210

With the increasing production of synthetic materials, more microplastic fibers are being generated while washing clothes. Consequently, these particles are increasingly detected in the aquatic environment. Synthetic fibers produced via washing have a relatively high contribution to microplastic pollution. Hence, recent research on reducing the release of microplastic fibers is attracting considerable attention. In this study, fabric-specific analysis was performed by strictly controlling various factors, and each washing and drying process was improved by focusing on the mechanical factors affecting microplastic release. Furthermore, the mass of the collected microplastic fibers and their length distribution were measured. Fabric construction, including chemical composition and yarn type, impacted the microplastics released during washing and drying. Differences in the mechanical factors during washing helped to identify the physical factors affecting microplastic release. These results on the release of microplastics may provide a basis for developing a filter system that can minimize the unintended environmental consequences.…

PMID: 34960828

Aquatic environments are being polluted by microplastics primarily originating from the washing of synthetic textiles. Microfibers (MF), which are microplastics in synthetic fibers, are consistently introduced into the environment with each domestic laundry cycle. To address this issue, we developed a specialized MF capture "barbed filter" (BF) by transforming PET monofilaments of different diameters (0.4, 0.6, and 0.8 mm) into structures that closely resemble the characteristics of tarantula urticating hairs. BFs feature sharp barbs that effectively capture and retain microfibers of diverse lengths, surpassing the performance of conventional control filters. The BFs had a retention efficiency of 88-91 %, while the CFs had an efficiency of 79-86 %. Our findings revealed that the barbed filter significantly outperformed the conventional control filter in capturing microfibers due to its smaller pore size, shorter pore distance, and unique filter shape. This design not only enhances the surface area and friction, facilitating microfibril strong entrapment but also minimizes the probability of microfibril passage through the filter. This research offers a promising solution for reducing microfibril release from laundry and textile industrial wastewater. The implementation of BFs in real life has the potential to significantly reduce microplastic pollution and promote a cleaner and more sustainable environment.…

PMID: 38521254

Synthetic textiles are one of the significant contributors to microfiber pollution, a subclass of microplastics. The impact of microfibers on the environment is irreversible. Several attempts were made to mitigate and control the microfiber release from synthetic textiles by introducing filters and laundry aids in washing machines, whereas some came up with methods to modify the textile materials to release fewer fibers. Studies have related different textile properties with their microfiber release potential. However, moisture properties, one of the essential properties that determine comfort, are not well explored. Hence, this research attempted to mitigate the microfiber release by altering the hydrophilicity of the polyester fabrics through chemical treatment (sodium hydroxide) with the hypothesis that hydrophilicity reduces the microfiber release. Both woven and knitted polyester fabrics were treated with different concentrations of the alkali solution (0.25 M, 0.50 M, 0.75 M, 1.00 M) and evaluated for their microfiber release. Treated fabrics also showed variations in their moisture and physical properties. Woven fabrics showed reduced shedding compared to knitted fabrics due to their compact structure. The results showed that the increase in alkali concentration significantly reduced the microfiber release up to 89.6 % reduction with woven fabric (from 17.37 ± 1.55 fibers/sq.cm to 2.63 ± 0.23 fibers/sq.cm) and a reduction of 68 % was noted for knitted fabric treated with 0.75 M alkali concentration (from 24.38 ± 1.30 fibers/sq.cm to 8.74 ± 1.39 fibers/sq.cm). A higher negative correlation (r = 94 % for woven and 89 % for knitted) was noted between alkali concentration and microfiber release. The alkali treatment significantly reduced the average fiber length from 450 to 230 μm, and 63-93 % of the fibers identified were in size range of 100-500 μm. When the moisture properties of the alkali-treated fabrics are concerned, an increase in moisture properties reduces the microfiber release. Water contact angle and absorbency time positively correlated with microfiber release. However, the study did not show any significant effect of moisture regain percentage and vertical wicking on microfiber shedding. Except for abrasion resistance, the physical properties of alkali-treated fabric did not show any relationship with microfiber release. The study noted the order of factors influencing the microfiber release of polyester fabric as fabric structural parameters (Woven/Knits) > fabric hydrophilicity > fabric physical property.…

PMID: 36603614