דו״ח מאומת

Orthodontic fixtures provide conducive niche for microbial colonization and inter-kingdom biofilm formation, exacerbating oral hygiene challenges. Conventional mouthwashes, though effective, are associated with adverse effects and potential antimicrobial resistance. Oil-pulling is an Indian traditional method of oral detoxification. This study evaluates blend of six essential oils in Dant-Kanti-Gandush (referred as DKG) from Syzygium aromaticum, Mentha piperita, Eucalyptus globulus, Zanthoxylum armatum and Ocimum sanctum, mixed with coconut and sesame carrier oils, as a potential oil-pulling formulation. Gas chromatography-mass spectrometry confirmed phytochemical composition of DKG. Antimicrobial assays demonstrated MIC₅₀ of DKG ranging from 0.10%(v/v) to 0.45%(v/v) against Streptococcus pyogenes, Streptococcus mutans, Proteus mirabilis and Candida albicans. DKG delayed the exponential phase and perturbed the growth of these pathogens. At ≥ 1.0×MIC₅₀, DKG impaired cariogenic traits of S. mutans with reduced biofilm formation, acid production and lower survival under acidic stress. DKG inhibited biofilm formation, hyphal transition and depleted total ergosterol levels in C. albicans, thereby disrupting cell wall integrity. Scanning electron microscopy on orthodontic fixtures revealed that DKG reduced microbial density, disrupted bacterial aggregation and fragmented hyphae in cross-kingdom biofilms of S. mutans and C. albicans. These findings highlight plant-based DKG as an anticariogenic alternative for maintaining oral health in individuals with orthodontic fixtures.…

PMID: 41372343

<b>Objectives:</b> To evaluate and compare the plaque-reducing efficacy of sesame-based oil pulling versus distilled water in a randomized controlled, examiner-blinded parallel-group study. <b>Materials and Methods:</b> Forty participants with gingivitis (community periodontal index of treatment needs grade 1 or 2) were randomly assigned to either the test group (sesame-based oil) or the control group (distilled water). Participants were instructed to perform oil pulling daily in the morning for 15 min over an eight-week period. The Rustogi Modified Navy Plaque Index (RMNPI) and gingival bleeding index (GBI) were evaluated at the baseline, as well as after four and eight weeks. Additionally, biofilm samples were collected for microbiological analysis. <b>Results:</b> The RMNPI was statistically significantly reduced after eight weeks of pulling with sesame-based oil (<i>p</i> < 0.001), as well as with distilled water (<i>p</i> < 0.001), without a significant difference between the groups. The GBI was statistically significantly reduced after eight weeks of pulling with sesame-based oil (<i>p</i> < 0.002), as well as with distilled water (<i>p</i> < 0.002), without a significant difference between the groups. No significant microbiological changes were detected in biofilm samples. <b>Conclusions:</b> Both plaque and gingival indices significantly decreased with oil pulling after eight weeks of intervention. Preclinical studies are necessary to clarify the mechanism of plaque reduction by oil pulling.…

PMID: 40724659

This narrative review summarises "alternative" or "natural" over-the-counter (OTC) mouthwashes not covered elsewhere in this supplement and newly emerging products, as potential mouthwashes of the future. The "natural" mouthwashes reviewed include saltwater, baking soda, coconut oil, charcoal, propolis, seaweeds, and probiotics. Other than essential oils, it is apparent that their clinical effectiveness is still under debate, but there is some evidence to suggest that propolis reduces plaque and gingivitis. This review also covers the host immune response, via novel anti-inmmunomodulant mouthwashes, such as erythropoietin to reduce inflammation with oral mucositis (OM) after radiotherapy. The emerging concept of nanoparticle-containing mouthwashes, such as iron oxide, is further discussed for OM, this agent having the potential for more targeted delivery of chemical antimicrobials. Unfortunately, there are impacts on the environment of widening mouthwash use with more new products, including increased use of packaging, antimicrobial resistance, and possible detrimental effects on marine life. Further, there are roadblocks, relating to regularly approvals and side effects, that still need to be overcome for any OTC deivered immunomodulant or nanoformulation mouthwashes. Despite these caveats, there are many new mouthwashes under development, which could help manage major oral diseases such as caries, gingivitis, and periodontal disease.…

PMID: 37867066