דו״ח מאומת

Cosmetic products, especially perfumes and colognes, are widely used in various communities. However, the use of these products can have side effects on consumers. This article aims to review the relevant literature published up to August 2020 to determine whether perfumes and colognes can affect people's health. Relevant articles were identified through electronic search. A total of 562 articles were selected and finally 37 related articles were included in the study after the screening process. The results of this systematic study showed that phthalates, aldehydes, parabens and aluminum-based salts are the most important contaminants in aromatic products that cause side effects such as allergies, breast cancer, reproductive disorders, especially in males, skin allergies, nervous system damage and migraine headaches for consumers. The incidence of complications in people using these products depends on parameters such as age, gender, race, amount of substance consumed, duration of use and economic status, and regarding the relationship between diseases such as cancer, respiratory disorders and endocrine with common contaminants in aromatic products, incidence of these diseases is probable in consumers which require further research to prove.…

PMID: 35669814

Perfumes are complex mixtures composed of many fragrance ingredients, many of which are known to be only weak allergens when tested individually. It is therefore surprising that fragrance contact allergy is one of the most common forms of contact allergy. To investigate whether mixing different fragrance allergens leads to increased sensitization potency, and to examine the difference in the challenge response to one chemical in mice sensitized either with the mixture of allergens or with only the relevant allergen. CBA mice were sensitized with three different concentrations of three fragrance allergens alone or as a mixture. The sensitization and elicitation responses were measured by ear thickness plus infiltration of B and T cells and T cell proliferation in the draining lymph nodes. We found a dose-dependent sensitization response for each of the allergens. An increased response was seen when the allergens were mixed. A stronger challenge response to cinnamal was seen in mice sensitized with the allergen mixture than in mice sensitized with cinnamal alone. Our findings suggest that mixtures of allergens increase the primary response that potentiates the generation of memory T cells in response to the specific allergen. Thus, allergen mixtures enhance both induction and elicitation of contact allergy.…

PMID: 21767274

Impaired intestinal barrier function is a precursor to various metabolic diseases which can occur when the intestinal epithelium is directly exposed to certain dietary components. Previous studies have demonstrated the barrier disruptive effect of artificial sweeteners such as sucralose and saccharin, in the intestinal epithelium. In the present study, we aimed to evaluate the impact of 3 non-synthetic sweeteners, stevia, miraculin, and mogroside V, on Caco-2 monolayer barrier integrity, reactive oxygen species (ROS) production, and tight junction protein expression as compared to the artificial sweetener saccharin. Miraculin and mogroside V exerted a significant impact on cell numbers with decreased cell viability at both 24 and 48 h. ROS production was also significantly increased by miraculin and mogroside V and epithelial barrier function, assessed by transepithelial electrical resistance and FITC-dextran leak, was significantly disrupted with both miraculin and mogroside V. Stevia exhibited no effect on epithelial cell viability, ROS accumulation or barrier function, despite a range of concentrations investigated. Knockdown of the sweet taste receptor, T1R3, significantly attenuated miraculin- and mogroside V-induced loss of cell viability, ROS accumulation and barrier disruption suggesting a T1R3-dependent mechanism. Gene expression analysis revealed differential regulation of cell junction-related genes by mogroside V and miraculin with upregulated expression of genes such as CAV1, CLDN2 and CLDN10, and downregulated expression of genes such as CAV3 and CDH2. These findings demonstrate that miraculin and mogroside V, but not stevia, negatively regulate ROS formation and intestinal epithelial barrier function in a T1R3-dependent manner and potentially through modulation of tight junction proteins. This highlights the need for further investigation into the long-term dietary implications of natural sweeteners, particularly miraculin and mogroside V, on gut health.…

PMID: 41462549

Cosmetic products, especially perfumes and colognes, are widely used in various communities. However, the use of these products can have side effects on consumers. This article aims to review the relevant literature published up to August 2020 to determine whether perfumes and colognes can affect people's health. Relevant articles were identified through electronic search. A total of 562 articles were selected and finally 37 related articles were included in the study after the screening process. The results of this systematic study showed that phthalates, aldehydes, parabens and aluminum-based salts are the most important contaminants in aromatic products that cause side effects such as allergies, breast cancer, reproductive disorders, especially in males, skin allergies, nervous system damage and migraine headaches for consumers. The incidence of complications in people using these products depends on parameters such as age, gender, race, amount of substance consumed, duration of use and economic status, and regarding the relationship between diseases such as cancer, respiratory disorders and endocrine with common contaminants in aromatic products, incidence of these diseases is probable in consumers which require further research to prove.…

PMID: 35669814

<h4>Objective</h4>The etiology of multiple chemical sensitivity (MCS) is still debated, which is an obstacle to assessing treatment options. An analysis of the scientific literature combined with the clinical experience can suggest some avenues.<h4>Methods</h4>The etiology of MCS and its underlying mechanisms were reviewed from the scientific literature to identify the main factors contributing to its development. The results of the studies involving biomarkers and cerebral imaging techniques on MCS subjects were compared with those performed on subjects having the comorbidities of MCS. From the scientific literature and the experience in a clinical setting in occupational and environmental medicine, distinct types of MCS were looked for, with the application of the underlying mechanisms. The potential effectiveness of available treatments was also reviewed.<h4>Results</h4>Among many factors, unresolved emotional traumas causing chronic and acute stress reactions play an important role in the development of MCS and can be the basis for effective treatment. We identified three types of clinical presentations, called the accidental type, following a toxic exposure causing an associated emotional trauma, the associative type, following a repeated innocuous exposure in a threatening context, and the developmental type, following a traumatic childhood/adolescence causing hypervigilance and chronic stress/trauma-related disorders. We presented real cases to illustrate these types and the mechanisms behind their development, as well as effective resolution.<h4>Conclusions</h4>MCS and its comorbidities could be treated effectively when the underlying emotional trauma(s) are targeted using trauma-focused psychotherapy and other therapies. Diagnostic criteria, principles of treatment and prevention, and avenues for research were derived from this analysis.…

PMID: 39766460